Introduction: Breast cancer is the most common malignancy that affects women, and given the prevalence and importance of breast cancer, a study was designed to Comparison of Social Support and Perceived Stress in women with and without breast cancer referred to Mahdieh MRI & CT Scan center in Hamedan in 2013.

Methods: This cross-sectional study is conducted on 116 women with breast cancer and 116 women without breast cancer referred to Mahdieh MRI & CT Scan center of Hamadan(Iran) in 2013 using Random sampling method. Data have been collected with percived social support and percived stress Questionnaire and processed with SPSS-16 software using descriptive statistics, independent t, and chi-square tests.

Results: The mean perceived stress in patients with and without breast cancer was 44.62 and 34.15 respectively. Results obtained from data analysis showed that there was statistically significant difference between the two groups in terms of percived stress (P=0.04), this means that in patients with breast cancer perceived stress was higher than others. The average score of perceived social support in both group was 38.66 and 36.14 respectively. The favorable perceived social support were higher in those without breast cancer, But not exist a significant difference between the two groups in terms of social protection.

Conclusion: According to the results of this study are likely social support and perceived stress are very important factor affecting breast cancer. People with social support and perceived stress reduction can prevent breast cancer or decreased deaths from breast cancer.