fa بررسی ارتباط مواجهه با آلودگی هوا در دوران بارداری و خطر سقط خودبه‌خودی: یک مرور نظام‌مند آمار زیستی و اپیدمیولوژی Biostatistic & Epidemiology مقالات مروری نظام مند Systematic Review Article <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">سابقه و هدف</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">:</span></span></span> <span b="" lang="AR-SA" nazanin="" style="font-family:">هدف از این مطالعه، </span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">بررسی ارتباط بین قرارگیری در معرض آلودگی هوای محیطی در دوران بارداری و خطر سقط خودبه‌خودی بود. این بررسی به دنبال روشن کردن تأثیر آلودگی هوا بر سلامت بارداری و شناسایی شکاف‌ها و نیازهای پژوهشی در این حوزه است</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">.</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">روش‌ها: </span></span></span><span b="" lang="AR-SA" nazanin="" style="font-family:">پایگاه‌های اطلاعاتی</span><span dir="LTR" new="" roman="" style="font-family:" times=""> Web of Science</span><span b="" lang="AR-SA" nazanin="" style="font-family:">، </span><span dir="LTR" new="" roman="" style="font-family:" times="">PubMed </span><span b="" lang="AR-SA" nazanin="" style="font-family:">و</span><span dir="LTR" new="" roman="" style="font-family:" times=""> Scopus </span><span b="" lang="AR-SA" nazanin="" style="font-family:">به</span> <span b="" lang="AR-SA" nazanin="" style="font-family:">‌صورت نظام‌مند تا سپتامبر </span><span b="" lang="FA" nazanin="" style="font-family:">۲۰۲۵</span><span b="" lang="AR-SA" nazanin="" style="font-family:"> جست‌وجو شدند. هیچ محدودیت زمانی یا زبانی اعمال نشد و فهرست منابع مطالعات مرتبط نیز به‌صورت دستی بررسی شد. تمامی مطالعات اپیدمیولوژیک مرتبط وارد مرور شدند</span><span dir="LTR" new="" roman="" style="font-family:" times="">. </span><strong><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="font-weight:normal">ارزیابی کیفیت مطالعات توسط مقیاس</span></span></strong><strong><span dir="LTR" style="font-weight:normal"> Newcastle&ndash;Ottawa Scale (NOS) </span></strong><strong><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="font-weight:normal">انجام شد</span></span></strong><strong><span dir="LTR" style="font-weight:normal">.</span></strong><strong> </strong><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">یافته&shy;ها:</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">از میان </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">2034</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> مقاله شناسایی‌شده، تعداد </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">۶58</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> مقاله تکراری حذف شد. در مرحله اول، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">1376</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> مقاله برای بررسی انتخاب گردید که پس از مرور عنوان و چکیده، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">173</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> مقاله واجد شرایط بررسی کامل بودند. در نهایت، 15 مقاله با معیارهای ورود مطابقت داشتند. به‌طور کلی، نتایج این مطالعات نشان داد که قرارگیری در معرض آلاینده‌های هوا از جمله&nbsp; منوکسید کربن</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> (</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">CO</span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">) </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، دی‌اکسید گوگرد</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">(</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">SO₂</span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">) </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">، ذرات معلق کمتر از </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">۲.۵</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:"> میکرون</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> (</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">PM₂.₅</span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">) </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">و ازن</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> (</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">O₃</span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">) </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">می‌تواند با افزایش خطر سقط خودبه‌خودی همراه باشد</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">نتیجه&shy;گیری:</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" nazanin="" style="font-family:">بین نتایج مطالعات مرورشده ناهمخوانی قابل توجهی وجود دارد؛ با این حال، به نظر می‌رسد آلودگی هوای محیطی می‌تواند به‌عنوان یک عامل خطر بالقوه برای سقط خودبه‌خودی در نظر گرفته شود. انجام مطالعات بیشتر برای تأیید این یافته‌ها ضروری است</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">.</span></span></span></span></span></span></span></span> <p lang="en"><strong>Background and Objective:</strong></p> <p lang="en">The aim of this study was to investigate the association between exposure to ambient air pollution during pregnancy and the risk of spontaneous abortion. This review sought to clarify the impact of air pollution on pregnancy health and to identify research gaps and needs in this field.</p> <p lang="en"><strong>Methods:&nbsp;</strong>The Web of Science, PubMed, and Scopus databases were systematically searched through September 2025. No time or language restrictions were applied, and the reference lists of relevant studies were also manually screened. All eligible epidemiological studies were included in the review. The quality of the included studies was assessed using the Newcastle&ndash;Ottawa Scale (NOS).</p> <p lang="en"><strong>Results:&nbsp;</strong>Among the 2,034 records identified, 658 duplicate articles were removed. In the initial screening stage, 1,376 articles were assessed, of which 173 were considered eligible for full-text review after title and abstract screening. Ultimately, 15 studies met the inclusion criteria. Overall, the findings of these studies indicated that exposure to air pollutants, including carbon monoxide (CO), sulfur dioxide (SO₂), particulate matter less than 2.5 microns in diameter (PM₂.₅), and ozone (O₃), may be associated with an increased risk of spontaneous abortion.</p> <p lang="en"><strong>Conclusion:&nbsp;</strong>Considerable inconsistency existed across the findings of the reviewed studies; however, ambient air pollution appears to be a potential risk factor for spontaneous abortion. Further studies are required to confirm these findings.</p> آلودگی هوا, بارداری, سقط خودبه‌خودی, مرور نظام‌مند Air pollution, Pregnancy, Spontaneous abortion, Systematic review 0 0 http://psj.umsha.ac.ir/browse.php?a_code=A-10-1612-1&slc_lang=fa&sid=1 Younes Mohammadi یونس محمدی younesmohamadi@gmail.com 100319475328460017778 100319475328460017778 Yes Hamadan University of Medical Sciences دانشگاه علوم پزشکی همدان Sanaz Omidi ساناز امیدی sanaz.omidi91@gmail.com 100319475328460017779 100319475328460017779 No Hamadan University of Medical Sciences دانشگاه علوم پزشکی همدان