Introduction: Inappropriate emotional reactions such as stress, anxiety and depression is very evident in today’s societies, affecting and causing too many problems for nurses and patients. Therefore, this study aimed to determine the level of anxiety, stress, depression and the role of demographic variables in nurses in Fasa Valiasr hospitals, in 2014.

Methods: This was a descriptive analytical cross-sectional study on 142 nurses, who work in Fasa University of Medical Sciences, that were selected through random sampling in 2014. In order to collect the data, the questionnaire, consisting two part: demographic information and DASS-21 Depression questionnaire, was used. Data analysis was performed by the Spearman correlation coefficient and Mann-Whitney test, using SPSS version 22.

Results: According to the findings, (32%) of nurses suffer from depression, (19%) from anxiety and (52%) from stress. There was a significant relationship between work experience and the level of stress (P=0.035). Also a significant relationship between age and depression was found (P=0.006). But there wasn’t any significant relationship between depression, anxiety, stress and level of education, gender and marital status.

Conclusion: As the results show, depression, anxiety and stress can be seen in a significant number of nurses. Considering the important role of nurses in improvement and promotion of public health, elimination of underlying factors that cause emotional reactions in nursing must be addressed, as a health priority.