Introduction: Quality of work life (QWL) is a comprehensive program which leads to promotion of productivity, performance and satisfaction of staff. Occupational stress is, also, defined as individual`s physical, mental and emotional reactions which are experienced due to working life needs and changes. Therefore, this research aims to determine the relationship of QWL with occupational stress in Bu-Ali Sina university staff.

Methods: The study is a cross sectional-descriptive type carried out on 178 individuals of Bu-Ali Sina university staff. The data were collected through standard questionnaire of determining QWL and questionnaire of classification of individual`s stress. To test the hypotheses, Pearson correlation coefficient and Lambda test, by utilizing SPSS-16, were used.

Results: The results showed that the level of QWL in the population of the study was at the medium and there was a positive significant relationship between QWL and staff education (P=0.001) and between QWL and staff working experience (P=0.04). However, between QWL and sex, marital status and age no significant relationship was found. Based on Pearson correlation test, there was obtained a significant relationship between score of QWL mean and mean of individuals` stress (P=.0.004). In another word, the greater the individuals` QWL, the less stress they experience.

Conclusion: Regarding the research findings, managers should improve the level of QWL through cooperative programs and team working to reduce occupational stress in the workplace.