Giti Kalantarian, Roya Avazpoor Tarkalki, Roghayeh Abasali Poor Kabireh, Nasrin Sheikh, Zahra Karimi,
Volume 12, Issue 4 (Pajouhan Scientific Journal, Summer 2014)
Abstract
Introduction: Coagulation factor X is an important protein in the blood coagulation pathway. It contains significant structural features that affect its function. The purpose of this study was to investigate the structural-functional features of activated form of Factor X in the presence of calcium ions. Factor X consists of 4 domains. Gamma-carboxyl glutamic acid (GLA) domain contains negatively charged and hydrophobic amino acids. These two amino acid groups with contrasting characteristics are responsible for binding to calcium ions and the membrane respectively, so it provides appropriate folding of Factor X in the presence of calcium ions. Epidermal growth factor-like domain (Epidermal growth Factor) which includes EGF1 and EGF2, is the edge between GLA and serine protease domain (SP) and it is involved in binding calcium.
Methods: Gathering and collecting of data has been done from molecular research in this area. It includes descriptions of three-dimensional structural characteristics of the Factor X.
Conclusion: The catalytic role of Factor X is performed by SP domain which made the heavy chain of factor X. Amino acids of SP domain play role in binding factor X to different activator and inhibitor.
Mona Rezapour Esfahani, Leila Jouybari, Parastoo Ghasemzadeh Pirsara, Arash Rezaee Shahmirzadi, Elham Mobaseri , Akram Sanagoo, Soheyla Kalantari ,
Volume 16, Issue 1 (Pajouhan Scientific Journal, Autumn 2017)
Abstract
Background and Objectives: Preeclampsia is the third leading cause of maternal mortality in the world. Despite extensive studies, its etiology remains unknown. Determining the incidence and the risk factors of the disorder in different regions can be useful in diagnosis, treatment and prevention of complications. The aim of this study was to determine the incidence of preeclampsia and its related factors in the women admitted to obstetrics and gynecology ward of Shahid Sayyad Shirazi Hospital.
Materials and Methods: In this descriptive cross-sectional study, 572 high risk pregnant women referred to obstetrics and gynecology department of Shahid Sayyad Shirazi Teaching Hospital in Gorgan during April to March 2013 were evaluated using valid checklist. Data were analyzed by SPSS software version 16 and descriptive statistics.
Results: Among total of 572 records, 43 women were known preeclampsia cases and 17 of them were eclampsia. The incidence of preeclampsia was 7.51% and ecclampsia was 2.97%. The mean age of hospitalized mothers due to preeclampsia was 29.11 years. 55.8% of mothers were in age range of 26-35 years. Five percents of the mothers had a history of cardiovascular disease and 28.3% had a history of hypertension.
Conclusions: Maternal hospitalization due to preeclampsia was high among other serious pregnancy problems. The prevalence of preeclampsia in our study population was significantly different from global statistics requiring further investigation.
