Introduction: Normal and abnormal of each society depends on general conditions of the families. Most of interventions and couple therapy methods seek to enhance the marital satisfaction and quality of life in incompatible couples. The purpose of this study was to indicate the effectiveness of therapy based on improving quality of life in incompatible couples.

Methods: This was a quasi-experimental pre-test/post-test design with a control group. Of all subjects, referred to the welfare institution of Shiraz in 2011, thirty couples were divided by random sampling into experimental and control groups (each including fifteen couples). Subjects of experimental group received 8 sessions of intervention. Meanwhile, the subjects of control group were placed in waiting list. The data was collected by SF-36 quality of life scale. Data analysis, moreover, was done through multivariate covariance using SPSS-16.

Results: Results of covariance analysis showed that quality of life therapy improves the quality of life in general (P˂0.001). Also, there was a significant difference for physical functioning, physical limitation, pain tolerance, vitality and emotional and social limitation indices between two groups (P˂0.001). However, no significant discrepancy was seen for general health, social role functioning and mental health (P>0.05).

Conclusion: According to these results, it can be concluded that therapy based on improving the quality of life enhances the life quality of these couples. Therefore, designing such programs can elevate the well-being and quality of life in incompatible couples.