Volume 21, Issue 3 (Pajouhan Scientific Journal, Summer 2023)                   Pajouhan Sci J 2023, 21(3): 204-212 | Back to browse issues page

Ethics code: IR.GOUMS.REC. 1400.447

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Momeni F, Joshghani H R, Arefnia S. Investigation of the Serum Levels of Zinc, Copper, and Magnesium in Children and Adolescents with Type 1 Diabetes. Pajouhan Sci J 2023; 21 (3) :204-212
URL: http://psj.umsha.ac.ir/article-1-1022-en.html
1- Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Pediatrics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran , drarefniya@goums.ac.ir
Abstract:   (505 Views)
Background and Objectives: Type 1 diabetes is a metabolic disorder in glucose metabolism. Poor glycemic control in type 1 diabetes mellitus (T1DM) commonly leads to oxidative stress and further diabetic complications. Trace elements, such as magnesium (Mg), zinc (Zn), and copper (Cu), play a role in the process of lipid peroxidation, pathogenesis, and exacerbation of diabetic complications. The present study aimed to investigate trace elements in children and adolescents with type 1 diabetes in Golestan province in 2022.
Materials and Methods: This case-control study was conducted on 26 children with type 1 diabetes and 26 non-diabetic children. After 12 hours of overnight fasting, 2 ml of venous blood was taken from the samples. Data were analyzed in SPSS software (version 18) using chi-score and logistic regression tests at a significance level of 0.05.
Results: The serum level of zinc was lower than the normal level in 42.3% of children with diabetes and 15.4% of the non-diabetic group. Moreover, the serum levels of copper and magnesium were lower than normal in 7.7% and 11.5% of children with diabetes, respectively. Body mass index, gender, and duration of diabetes demonstrated no significant relationship with zinc, copper, and magnesium levels.
Conclusion: Having type 1 diabetes causes a decrease in serum levels of zinc and copper in children. According to body mass profile, gender and duration of diabetes are not associated with this serum reduction.

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Type of Study: Research Article | Subject: Medicine & Clinical Sciences
Received: 2023/05/28 | Accepted: 2023/07/10 | Published: 2023/09/22

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