Volume 21, Issue 3 (Pajouhan Scientific Journal, Summer 2023)
Pajouhan Sci J 2023, 21(3): 196-203 |
Back to browse issues page
Ethics code: IR.GOUMS.REC. 1400.447
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Momeni F, Joshghani H R, Arefnia S. Investigation of the Serum Levels of Zinc, Copper, and Magnesium in Children and Adolescents with Type 1 Diabetes. Pajouhan Sci J 2023; 21 (3) :196-203
URL: http://psj.umsha.ac.ir/article-1-1022-en.html
URL: http://psj.umsha.ac.ir/article-1-1022-en.html
1- Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Pediatrics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ,drarefniya@goums.ac.ir
2- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Pediatrics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (811 Views)
Background and Objectives: Type 1 diabetes is a metabolic disorder in glucose metabolism. Poor glycemic control in type 1 diabetes mellitus (T1DM) commonly leads to oxidative stress and further diabetic complications. Trace elements, such as magnesium (Mg), zinc (Zn), and copper (Cu), play a role in the process of lipid peroxidation, pathogenesis, and exacerbation of diabetic complications. The present study aimed to investigate trace elements in children and adolescents with type 1 diabetes in Golestan province in 2022.
Materials and Methods: This case-control study was conducted on 26 children with type 1 diabetes and 26 non-diabetic children. After 12 hours of overnight fasting, 2 ml of venous blood was taken from the samples. Data were analyzed in SPSS software (version 18) using chi-score and logistic regression tests at a significance level of 0.05.
Results: The serum level of zinc was lower than the normal level in 42.3% of children with diabetes and 15.4% of the non-diabetic group. Moreover, the serum levels of copper and magnesium were lower than normal in 7.7% and 11.5% of children with diabetes, respectively. Body mass index, gender, and duration of diabetes demonstrated no significant relationship with zinc, copper, and magnesium levels.
Conclusion: Having type 1 diabetes causes a decrease in serum levels of zinc and copper in children. According to body mass profile, gender and duration of diabetes are not associated with this serum reduction.
Materials and Methods: This case-control study was conducted on 26 children with type 1 diabetes and 26 non-diabetic children. After 12 hours of overnight fasting, 2 ml of venous blood was taken from the samples. Data were analyzed in SPSS software (version 18) using chi-score and logistic regression tests at a significance level of 0.05.
Results: The serum level of zinc was lower than the normal level in 42.3% of children with diabetes and 15.4% of the non-diabetic group. Moreover, the serum levels of copper and magnesium were lower than normal in 7.7% and 11.5% of children with diabetes, respectively. Body mass index, gender, and duration of diabetes demonstrated no significant relationship with zinc, copper, and magnesium levels.
Conclusion: Having type 1 diabetes causes a decrease in serum levels of zinc and copper in children. According to body mass profile, gender and duration of diabetes are not associated with this serum reduction.
Type of Study: Research Article |
Subject:
Medicine & Clinical Sciences
Received: 2023/05/28 | Accepted: 2023/07/10 | Published: 2023/09/22
Received: 2023/05/28 | Accepted: 2023/07/10 | Published: 2023/09/22
References
1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(1):81-90. [DOI:10.2337/dc14-S081] [PMID]
2. Gregory GA, Robinson TI, Linklater SE, Wang F, Colagiuri S, de Beaufort C, et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol. 2022;10(10):741-60. [DOI:10.1016/S2213-8587(22)00218-2] [PMID]
3. Alghobashy AA, Alkholy UM, Talat MA, Abdalmonem N, Zaki A, Ahmed IA, et al. Trace elements and oxidative stress in children with type 1 diabetes mellitus. Diabetes Metab Syndr Obes. 2018;11:85-92. [DOI:10.2147/DMSO.S157348] [PMID] []
4. Özenç S, Saldir M, Sarı E, Çetinkaya S, Yeşilkaya Ş, Babacan O, et al. Selenium, zinc, and copper levels and their relation with HbA1c status in children with type 1 diabetes mellitus. Int J Diabetes Dev Ctries. 2015;35:514-8. [DOI:10.1007/s13410-015-0327-y]
5. Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009;58(10):1477-82. [DOI:10.1016/j.metabol.2009.04.035] [PMID]
6. Praveeena S, Pasula S, Sameera K. Trace elements in diabetes mellitus. J Clin Diagn Res. 2013;7(9):1863.
7. Laclaustra M, Stranges S, Navas-Acien A, Ordovas JM, Guallar E. Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis. 2010;210(2):643-8. [DOI:10.1016/j.atherosclerosis.2010.01.005] [PMID] []
8. Al Alawi AM, Majoni SW, Falhammar H. Magnesium and human health: perspectives and research directions. Int J Endocrinol. 2018:1-17. [DOI:10.1155/2018/9041694] [PMID] []
9. Sanjeevi N, Freeland-Graves J, Beretvas SN, Sachdev PK. Trace element status in type 2 diabetes: A meta-analysis. J Clin Diagn Res. 2018 May;12(5):OE01-OE08. [DOI:10.7860/JCDR/2018/35026.11541] [PMID] []
10. Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, et al. Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res. 2013;156:79-90. [DOI:10.1007/s12011-013-9858-6] [PMID]
11. Lin CC, Tsweng GJ, Lee CF, Chen BH, Huang YL. Magnesium, zinc, and chromium levels in children, adolescents, and young adults with type 1 diabetes. Clin Nutr. 2016;35(4):880-4.. [DOI:10.1016/j.clnu.2015.05.022] [PMID]
12. Shiva S, Saboktakin L, Ghorbanihaghjo A, Rafiee A. Serum zinc level in children with type one diabetes mellitus. J Urmia Univ Med Sci. 2013;24(2):104-9.
13. Saboktakin L. Serum Magnesium Levels in Children with Type 1 Diabetes Mellitus in Northwest Iran. Int J Pediatr. 2022;10(6):16214-16222. DOI: 10.22038/ijp. 2022.63730.4849.
14. Marjanac I, Biljan B, Husarić E, Canecki-Varžić S, Pavela J, Lovrić R. Magnesium, zinc and iron serum levels as potential parameters significant for effective glycemic control in children with type 1 diabetes. Clin Diabetol. 2020;9(3):161-6. [DOI:10.5603/DK.2020.0014]
15. Uğurlu V, Binay Ç, Şimşek E, Bal C. Cellular Trace Element Changes in Type 1 Diabetes Patients. J Clin Res Pediatr Endocrinol. 2016;8(2):180-6. [DOI:10.4274/jcrpe.2449] [PMID] []
16. Zhang Y, Li Q, Xin Y, Lv W, Ge C. Association between serum magnesium and common complications of diabetes mellitus. Technol Health Care. 2018;26(1): 379-87. [DOI:10.3233/THC-174702] [PMID] []
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences.
Published by UMSHA Press
Journal Tel: +98 81 38380090
Publisher Tel: +98 81 38382022
Website: https://psj.umsha.ac.ir/
Email: psj@umsha.ac.ir
