Volume 21, Issue 4 (Pajouhan Scientific Journal, Autumn 2023)
Pajouhan Sci J 2023, 21(4): 235-242 |
Back to browse issues page
Research code: 111203-29
Ethics code: IR.GOUMS.REC.1398.308
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Moeini F, Mostaghimi M, Honarvar M, Sharifi A. Comparison of Dietary Intake of Zinc, Copper, Selenium, and Manganese in Children Having Autism Spectrum Disorders with Healthy Control Children. Pajouhan Sci J 2023; 21 (4) :235-242
URL: http://psj.umsha.ac.ir/article-1-1043-en.html
URL: http://psj.umsha.ac.ir/article-1-1043-en.html
1- Student Research Committee, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
2- Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
3- Golestan Research Center of Gastroenterology and Hepatology, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran , a.sharifi1983@gmail.com
2- Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
3- Golestan Research Center of Gastroenterology and Hepatology, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran , a.sharifi1983@gmail.com
Abstract: (492 Views)
Background and Objectives: Children with autism spectrum disorders (ASD) are at risk of insufficient nutrient intake due to inappropriate eating habits, problems in sensory perception, and choosing monotonous foods. Minerals play an essential role in the central nervous system, and their deficiency or excess can cause a variety of health issues and can contribute to the development of ASD. This study aimed to compare the dietary intake of zinc, copper, selenium, and manganese in two groups of children, with ASD and healthy controls, in Gorgan City, Iran.
Materials and Methods: In this study, the food intake of 35 ASD children aged 6 to 12 years and 70 healthy children was recorded using the semi-quantitative Food Frequency Questionnaire. The average daily intake of zinc, copper, selenium, and manganese was estimated using ShaFA software.
Results: There was no statistically significant difference in the dietary intake of zinc, copper, and selenium; however, the intake of manganese was significantly lower in ASD children (median±IQR: 2.39±1.83) than in healthy children (median±IQR: 3.24±1.94; P=0.03).
Conclusion: Considering the existence of problems related to eating habits in children with ASD, the results of this study showed the necessity of frequent and regular nutrition assessment for ASD children. Studies with larger sample sizes are recommended.
Materials and Methods: In this study, the food intake of 35 ASD children aged 6 to 12 years and 70 healthy children was recorded using the semi-quantitative Food Frequency Questionnaire. The average daily intake of zinc, copper, selenium, and manganese was estimated using ShaFA software.
Results: There was no statistically significant difference in the dietary intake of zinc, copper, and selenium; however, the intake of manganese was significantly lower in ASD children (median±IQR: 2.39±1.83) than in healthy children (median±IQR: 3.24±1.94; P=0.03).
Conclusion: Considering the existence of problems related to eating habits in children with ASD, the results of this study showed the necessity of frequent and regular nutrition assessment for ASD children. Studies with larger sample sizes are recommended.
Type of Study: Research Article |
Subject:
Basic Sciences
Received: 2023/08/19 | Accepted: 2023/08/29 | Published: 2023/12/1
Received: 2023/08/19 | Accepted: 2023/08/29 | Published: 2023/12/1
References
1. Arons MH, Lee K, Thynne CJ, Kim SA, Schob C, Kindler S, Montgomery JM, Garner CC. Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength. J Neurosci. 2016;36(35):9124-34. [DOI:10.1523/JNEUROSCI.0116-16.2016] [PMID] []
2. Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet. 2018;392(10146):508-20. [DOI:10.1016/S0140-6736(18)31129-2] [PMID]
3. Goyal DK, Neil J, Simmons S, Mansab F, Benjamin S, Pitfield V, et al. Zinc deficiency in autism: a controlled study. Insights in Biomedicine. 2019;4(03).
4. Alsufiani HM, Alkhanbashi AS, Laswad NAB, Bakhadher KK, Alghamdi SA, Tayeb HO, et al. Zinc deficiency and supplementation in autism spectrum disorder and Phelan‐McDermid syndrome. J Neurosci Res. 2022;100(4):970-8. [DOI:10.1002/jnr.25019] [PMID]
5. Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R. Genetics of autistic disorders: review and clinical implications. Eur Child Adolesc Psychiatry. 2010;19(3):169-78. [DOI:10.1007/s00787-009-0076-x] [PMID] []
6. Blaurock-Busch E, DESSOKI HH, RABAH T. Toxic metals and essential elements in hair and severity of symptoms among children with autism. Maedica. 2012;7(1):38. [DOI:10.1016/S0924-9338(12)74444-9]
7. Lai X, Zhang Q, Zhu J, Yang T, Guo M, Li Q, et al. A weekly vitamin A supplementary program alleviates social impairment in Chinese children with autism spectrum disorders and vitamin A deficiency. Eur J Clin Nutr. 2021;75(7):1118-25. [DOI:10.1038/s41430-020-00827-9] [PMID]
8. Dufault R, Lukiw WJ, Crider R, Schnoll R, Wallinga D, Deth R. A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clin Epigenetics 2012;4(1):6. [DOI:10.1186/1868-7083-4-6] [PMID] []
9. Bjorklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp (Wars). 2013;73(2):225-36. [DOI:10.55782/ane-2013-1932] [PMID]
10. Frassinetti S, Bronzetti G, Caltavuturo L, Cini M, Croce CD. The role of zinc in life: a review. J Environ Pathol Toxicol Oncol 2006;25(3):597-610. [DOI:10.1615/JEnvironPatholToxicolOncol.v25.i3.40] [PMID]
11. Andreini C, Banci L, Bertini I, Rosato A. Counting the zinc-proteins encoded in the human genome. J Proteome Res. 2006;5(1):196-201. [DOI:10.1021/pr050361j] [PMID]
12. Behl S, Mehta S, Pandey MK. Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review. Front Mol Neurosci. 2020;13:586209. [DOI:10.3389/fnmol.2020.586209] [PMID] []
13. Chowanadisai W, Kelleher SL, Lönnerdal B. Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood. J Neurochem 2005;94(2):510-9. [DOI:10.1111/j.1471-4159.2005.03246.x] [PMID]
14. Babaknejad N, Sayehmiri F, Sayehmiri K, Mohamadkhani A, Bahrami S. The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis. Iran J Child Neurol. 2016;10(4):1-9.
15. Sensi SL, Paoletti P, Bush AI, Sekler I. Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci. 2009;10(11):780-91. [DOI:10.1038/nrn2734] [PMID]
16. Faber S, Zinn GM, Kern JC 2nd, Kingston HM. The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers. 2009;14(3):171-80. [DOI:10.1080/13547500902783747] [PMID]
17. Leary SC, Winge DR, Cobine PA. "Pulling the plug" on cellular copper: the role of mitochondria in copper export. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2009;1793(1):146-53. [DOI:10.1016/j.bbamcr.2008.05.002] [PMID] []
18. Li S-o, Wang J-l, Bjørklund G, Zhao W-n, Yin C-h. Serum copper and zinc levels in individuals with autism spectrum disorders. Neuroreport. 2014;25(15):1216-20. [DOI:10.1097/WNR.0000000000000251] [PMID]
19. Uriu-Adams JY, Keen CL. Copper, oxidative stress, and human health. Mol Aspects Med. 2005;26(4-5):268-98. [DOI:10.1016/j.mam.2005.07.015] [PMID]
20. Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology. 2006;13(3):171-81.
https://doi.org/10.1016/j.pathophys.2006.05.007 [DOI:10.1016/j.pathophys.2006.05.004] [PMID]
21. Raymond LJ, Deth RC, Ralston NV. Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology. Autism Res Treat. 2014;2014:164938. [DOI:10.1155/2014/164938] [PMID] []
22. Tinkov AA, Skalnaya MG, Simashkova NV, Klyushnik TP, Skalnaya AA, Bjørklund G, et al. Association between catatonia and levels of hair and serum trace elements and minerals in autism spectrum disorder. Biomed Pharmacother. 2019;109:174-80. [DOI:10.1016/j.biopha.2018.10.051] [PMID]
23. Wu H, Zhao G, Liu S, Zhang Q, Wang P, Cao Y, et al. Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism disease model. J Nutr Biochem. 2022;107:109034. [DOI:10.1016/j.jnutbio.2022.109034] [PMID]
24. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, et al. Manganese homeostasis in the nervous system. J Neurochem. 2015;134(4):601-10. [DOI:10.1111/jnc.13170] [PMID] []
25. Ijomone OM, Olung NF, Akingbade GT, Okoh COA, Aschner M. Environmental influence on neurodevelopmental disorders: Potential association of heavy metal exposure and autism. J Trace Elem Med Biol. 2020;62:126638. [DOI:10.1016/j.jtemb.2020.126638] [PMID] []
26. Moeini F, Mostaghimi M, Honarvar M R, Sharifi A. Comparison of Dietary Intake of Vitamin A in Children with Autism Spectrum Disorders with Healthy Children in Gorgan City in 2021: A Case-control Study.[in persian]. Pajouhan Sci J .2023; 21 (2) :97-103.
27. Sharifi A. ShaFA, A new Microsoft windows-based software for food intake analysis. JNFS. 2023. [DOI:10.18502/jnfs.v9i1.14834]
28. De Palma G, Catalani S, Franco A, Brighenti M, Apostoli P. Lack of correlation between metallic elements analyzed in hair by ICP-MS and autism. J Autism Dev Disord. 2012;42(3):342-53. [DOI:10.1007/s10803-011-1245-6] [PMID]
29. Russo AJ. Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease. Nutr Metab Insights. 2011;4:49-54. [DOI:10.4137/NMI.S6827] [PMID] []
30. Adams JB, Romdalvik J, Ramanujam VM, Legator MS. Mercury, lead, and zinc in baby teeth of children with autism versus controls. J Toxicol Environ Health A. 2007;70(12):1046-51. [DOI:10.1080/15287390601172080] [PMID]
31. Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab (Lond). 2011;8:1-32. [DOI:10.1186/1743-7075-8-34] [PMID] []
32. El-Baz F, Mowafy ME, Lotfy A. Study of serum copper and ceruloplasmin levels in Egyptian autistic children. Egyptian Journal of Medical Human Genetics. 2018;19(2):113-6. [DOI:10.1016/j.ejmhg.2017.08.002]
33. Al-Farsi YM, Waly MI, Al-Sharbati MM, Al-Shafaee MA, Al-Farsi OA, Al-Khaduri MM, et al. Levels of heavy metals and essential minerals in hair samples of children with autism in Oman: a case-control study. Biol Trace Elem Res. 2013;151:181-6. [DOI:10.1007/s12011-012-9553-z] [PMID]
34. Lakshmi Priya MD, Geetha A. Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biol Trace Elem Res. 2011;142(2):148-58. [DOI:10.1007/s12011-010-8766-2] [PMID]
35. Hyman SL, Stewart PA, Schmidt B, Cain U, Lemcke N, Foley JT, et al. Nutrient intake from food in children with autism. Pediatrics. 2012;130(Sup2):S145-S53. [DOI:10.1542/peds.2012-0900L] [PMID] []
36. Skalny AV, Skalnaya MG, Bjørklund G, Gritsenko VA, Aaseth J, Tinkov AA. Selenium and Autism Spectrum Disorder. Molecular and Integrative Toxicology Selenium. 2018: 193-210. [DOI:10.1007/978-3-319-95390-8_10]
37. Moskovitz J, Stadtman ER. Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues. Proc Natl Acad Sci U S A. 2003;100(13):7486-90. [DOI:10.1073/pnas.1332607100] [PMID] []
38. Saghazadeh A, Ahangari N, Hendi K, Saleh F, Rezaei N. Status of essential elements in autism spectrum disorder: systematic review and meta-analysis. Rev Neurosci. 2017;28(7):783-809. [DOI:10.1515/revneuro-2017-0015] [PMID]
39. Claus Henn B, Ettinger AS, Schwartz J, Téllez-Rojo MM, Lamadrid-Figueroa H, Hernández-Avila M, et al. Early postnatal blood manganese levels and children's neurodevelopment.Epidemiology. 2010;21(4):433-9. [DOI:10.1097/EDE.0b013e3181df8e52] [PMID] []
40. Abdullah MM, Ly AR, Goldberg WA, Clarke-Stewart KA, Dudgeon JV, Mull CG, Chan TJ, Kent EE, Mason AZ, Ericson JE. Heavy metal in children's tooth enamel: related to autism and disruptive behaviors? J Autism Dev Disord. 2012;42(6):929-36. [DOI:10.1007/s10803-011-1318-6] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences.
Published by UMSHA Press
Journal Tel: +98 81 38380090
Publisher Tel: +98 81 38382022
Website: https://psj.umsha.ac.ir/
Email: psj@umsha.ac.ir
