Volume 23, Issue 2 (Pajouhan Scientific Journal, Spring 2025)
Pajouhan Sci J 2025, 23(2): 82-91 |
Back to browse issues page
Ethics code: IR.UMSHA.REC.1400.290
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Karkhanei B, Haghani A, Talebi Ghane E, Pouramiri R, Shalchi Z, Razaghi M et al . Investigation of the Relationship between Total Oxidative Status (TOS) and Total Antioxidant Capacity (TAC) with the Severity of COVID-19 Disease in Children Hospitalized in Besat Hospital in Hamadan (Iran). Pajouhan Sci J 2025; 23 (2) :82-91
URL: http://psj.umsha.ac.ir/article-1-1151-en.html
URL: http://psj.umsha.ac.ir/article-1-1151-en.html
Behrouz Karkhanei1 
, Amireza Haghani1 , Elahe Talebi Ghane2 , Rahim Pouramiri3 , Zohreh Shalchi4 , Mahta Razaghi5 , Fereshteh Mehri *6
, Amireza Haghani1 , Elahe Talebi Ghane2 , Rahim Pouramiri3 , Zohreh Shalchi4 , Mahta Razaghi5 , Fereshteh Mehri *6
1- Department of Anesthesiology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Noncommunicable Disease Modeling Research Center, Institute of Health Sciences and Technology, Hamadan University of Medical Sciences, Hamadan, Iran
3- Pediatrician and Board of Renal Diseases Specialist, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, Faculty of Medicine, Ekbatan Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Pathology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
6- Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran ,freshteh_mehri@yahoo.com
2- Noncommunicable Disease Modeling Research Center, Institute of Health Sciences and Technology, Hamadan University of Medical Sciences, Hamadan, Iran
3- Pediatrician and Board of Renal Diseases Specialist, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, Faculty of Medicine, Ekbatan Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Pathology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
6- Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (735 Views)
Background and Objectives: The present study was conducted to investigate the relationship between the level of oxidant capacity and total antioxidant capacity (TAC) with the severity of the disease in children with COVID-19 hospitalized in Besat Hospital in Hamadan (Iran) in 2021.
Materials and Methods: In this cross-sectional study, 90 children hospitalized in pediatric wards of Besat Hospital, Hamadan, were included. The patients were divided into two groups: the first group of patients without COVID-19 and the second group of patients with COVID-19 who were diagnosed by the attending physician in the inpatient ward. 3 cc of blood samples were taken from each group to determine the total oxidant status (TOS) and TAC. The statistical significance level was set at 0.05.
Results: In comparing OS biomarker factors between healthy and COVID children, this study showed no significant difference in the mean TOS, and TAC between the healthy and diseased groups (P>0.05). There was also no significant difference in mean TOS in different age groups. However, a difference in the mean TAC was observed in groups. In addition, the mean TAC was highest in children under 2 years of age and lowest in the 2-6-year-old group.
Conclusion: The findings of the present study indicate that, in general, the level of OS is not higher in infected patients. This issue is partially compensated by increasing TAC levels, such that the level of OS in patients is not significantly different from that in healthy individuals.
Materials and Methods: In this cross-sectional study, 90 children hospitalized in pediatric wards of Besat Hospital, Hamadan, were included. The patients were divided into two groups: the first group of patients without COVID-19 and the second group of patients with COVID-19 who were diagnosed by the attending physician in the inpatient ward. 3 cc of blood samples were taken from each group to determine the total oxidant status (TOS) and TAC. The statistical significance level was set at 0.05.
Results: In comparing OS biomarker factors between healthy and COVID children, this study showed no significant difference in the mean TOS, and TAC between the healthy and diseased groups (P>0.05). There was also no significant difference in mean TOS in different age groups. However, a difference in the mean TAC was observed in groups. In addition, the mean TAC was highest in children under 2 years of age and lowest in the 2-6-year-old group.
Conclusion: The findings of the present study indicate that, in general, the level of OS is not higher in infected patients. This issue is partially compensated by increasing TAC levels, such that the level of OS in patients is not significantly different from that in healthy individuals.
Type of Study: Research Article |
Subject:
Medicine & Clinical Sciences
Received: 2024/12/25 | Accepted: 2025/04/22 | Published: 2025/08/17
Received: 2024/12/25 | Accepted: 2025/04/22 | Published: 2025/08/17
References
1. Gümüş H, Erat T, Öztürk İ, Demir A, Koyuncu I. Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19. J Med Virol. 2022; 94(5): 2259-2264. [DOI:10.1002/jmv.27640] [PMID]
2. Aydin O, Oğuz Kaynak M, Sabuncuoglu S, Girgin G, Derin Oygar P, Ozsurekci Y, et al. The effects of COVID-19 on oxidative stress and antioxidant defense mechanism in children. J Pediatric Infect Dis. 2022;17(02): 112-118. [DOI:10.1055/s-0042-1743577]
3. Perrone S, Cannavò L, Manti S, Rulli I, Buonocore G, Esposito SMR, et al. Pediatric multisystem syndrome associated with SARS-CoV-2 (MIS-C): the interplay of oxidative stress and inflammation. Int J Mol Sci. 2022;23(21): 12836. [DOI:10.3390/ijms232112836] [PMID]
4. Rychkova LV, Darenskaya MA, Semenova NV, Kolesnikov SI, Petrova AG, Nikitina OA. Oxidative stress intensity in children and adolescents with a new coronavirus infection. Int J Biomed. 2022;12(2):242-246. [DOI:10.21103/Article12(2)_OA7]
5. Bakadia BM, Boni BOO, Ahmed AAQ, Yang G. The impact of oxidative stress damage induced by the environmental stressors on COVID-19. Life sci. 2021;264: 118653. [DOI:10.1016/j.lfs.2020.118653] [PMID]
6. Khan G. A novel coronavirus capable of lethal human infections: an emerging picture. Virol J. 2013; 10(1): 66. [DOI:10.1186/1743-422X-10-66] [PMID]
7. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio. 2012;3(6):e00473-12. [DOI:10.1128/mBio.00473-12] [PMID]
8. Drosten C, Seilmaier M, Corman VM, Hartmann W, Scheible G, Sack S, et al. Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis. 2013;13(9): 745-751. [DOI:10.1016/S1473-3099(13)70154-3] [PMID]
9. Lake MA. What we know so far: COVID-19 current clinical knowledge and research. Clin Med. 2020;20(2): 124-127. [DOI:10.7861/clinmed.2019-coron] [PMID]
10. Chang R, Ng TB, Sun WZ. Lactoferrin as potential preventative and treatment for COVID-19. Int J Antimicrob Agents. 2020;56(3):106118. [DOI:10.1016/j.ijantimicag.2020.106118] [PMID]
11. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529-539. [DOI:10.1007/s00281-017-0629-x] [PMID]
12. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. J Med Virol. 2020;92(4):424-432. [DOI:10.1002/jmv.25685] [PMID]
13. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420-422. [DOI:10.1016/S2213-2600(20)30076-X] [PMID]
14. Peng S, Zhang B, Yao J, Duan D, Fang J. Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells. Food Funct. 2015;6(6): 2091-2100. [DOI:10.1039/C5FO00097A] [PMID]
15. Ghazavi A, Mosayebi G, Solhi H, Rafiei M, Moazzeni SM. Serum markers of inflammation and oxidative stress in chronic opium (Taryak) smokers. Immunol Lett. 2013;153(1): 22-26. [DOI:10.1016/j.imlet.2013.07.001] [PMID]
16. Graciano-Machuca O, Villegas-Rivera G, López-Pérez I, Macías-Barragán J, Sifuentes-Franco S. Multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection: role of oxidative stress. Front Immunol. 2021;12: 723654. [DOI:10.3389/fimmu.2021.723654] [PMID]
17. Chernyak BV, Popova EN, Prikhodko AS, Grebenchikov OA, Zinovkina LA, Zinovkin RA. COVID-19 and oxidative stress. Biochemistry (Mosc). 2020;85: 1543-1553. [DOI:10.1134/S0006297920120068] [PMID]
18. Ebrahimi M, Norouzi P, Aazami H, Moosavi-Movahedi AA. Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach. Int J Biol Macromol. 2021;189: 802-818. [DOI:10.1016/j.ijbiomac.2021.08.095] [PMID]
19. Mehri F, Rahbar AH, Ghane ET, Souri B, Esfahani M. Changes in oxidative markers in COVID-19 patients. Arch Med Res. 2021;52(8): 843-849. [DOI:10.1016/j.arcmed.2021.06.004] [PMID]
20. Yaghoubi N, Youssefi M, Jabbari Azad F, Farzad F, Yavari Z, Zahedi Avval F. Total antioxidant capacity as a marker of severity of COVID‐19 infection: Possible prognostic and therapeutic clinical application. J Med Virol. 2022; 94(4): 1558-1565. [DOI:10.1002/jmv.27500] [PMID]
21. Tsermpini EE, Glamočlija U, Ulucan-Karnak F, Redenšek Trampuž S, Dolžan V. Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19: a systematic review. Antioxidants. 2022;11(8): 1609. [DOI:10.3390/antiox11081609] [PMID]
22. Karkhanei B, Talebi Ghane E, Mehri F. Evaluation of oxidative stress level: Total antioxidant capacity, total oxidant status and glutathione activity in patients with COVID-19. New Microbes New Infect. 2021;42: 100897. [DOI:10.1016/j.nmni.2021.100897] [PMID]
23. Wolszczak-Biedrzycka B, Dorf J, Matowicka-Karna J, Dymicka-Piekarska V, Wojewódzka-Żeleźniakowicz M, Żukowski P, Zalewska A, et al. Redox biomarkers-An effective tool for diagnosing COVID-19 patients and convalescents. J Inflamm Res. 2024;17: 2589-2607. [DOI:10.2147/JIR.S456849] [PMID]
24. Javanbakht MH, Sadria R, Djalali M, Derakhshanian H, Hosseinzadeh P, Zarei M, et al. Soy protein and genistein improves renal antioxidant status in experimental nephrotic syndrome. Nefrologia. 2014;34(4):483-490.
25. Aleksandrova K, Koelman L, Rodrigues CE. Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies. Redox Biol. 2021; 42: 101869. [DOI:10.1016/j.redox.2021.101869] [PMID]
26. Massalska MA, Gober HJ. How children are protected from COVID-19? A historical, clinical, and pathophysiological approach to address COVID-19 susceptibility. Front Immunol. 2021; 12: 646894. [DOI:10.3389/fimmu.2021.646894] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences.
Published by UMSHA Press
Journal Tel: +98 81 38380090
Publisher Tel: +98 81 38382022
Website: https://psj.umsha.ac.ir/
Email: psj@umsha.ac.ir
