Volume 23, Issue 2 (Pajouhan Scientific Journal, Spring, In Press 2025)
Pajouhan Sci J 2025, 23(2): 0-0 |
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Ethics code: IR.UMSHA.REC.1400.290
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Karkhanei B, Haghani A, Talebi Ghane E, Pouramiri R, Shalchi Z, Razaghi M et al . Investigation of the Relationship between Total Oxidative Status (TOS) and Total Antioxidant Capacity (TAC) with the Severity of COVID-19 Disease in Children Hospitalized in Besat Hospital in Hamadan (Iran). Pajouhan Sci J 2025; 23 (2)
URL: http://psj.umsha.ac.ir/article-1-1151-en.html
URL: http://psj.umsha.ac.ir/article-1-1151-en.html
Behrouz Karkhanei1 
, Amireza Haghani1 , Elahe Talebi Ghane2 , Rahim Pouramiri3 , Zohreh Shalchi4 , Mahta Razaghi5 , Fereshteh Mehri *6
, Amireza Haghani1 , Elahe Talebi Ghane2 , Rahim Pouramiri3 , Zohreh Shalchi4 , Mahta Razaghi5 , Fereshteh Mehri *6
1- Department of Anesthesiology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Noncommunicable Disease Modeling Research Center, Institute of Health Sciences and Technology, Hamadan University of Medical Sciences, Hamadan, Iran
3- Pediatrician and Board of Renal Diseases Specialist, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, Faculty of Medicine, Ekbatan Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Pathology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
6- Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran ,freshteh_mehri@yahoo.com
2- Noncommunicable Disease Modeling Research Center, Institute of Health Sciences and Technology, Hamadan University of Medical Sciences, Hamadan, Iran
3- Pediatrician and Board of Renal Diseases Specialist, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Pediatrics, Faculty of Medicine, Ekbatan Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Pathology, Faculty of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
6- Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran ,
Abstract: (73 Views)
Background and Objectives: The present study was conducted to investigate the relationship between the level of oxidant capacity and total antioxidant capacity (TAC) with the severity of the disease in children with COVID-19 hospitalized in Besat Hospital in Hamadan (Iran) in 2021.
Materials and Methods: In this cross-sectional study, 90 children hospitalized in pediatric wards of Besat Hospital, Hamadan, were included. The patients were divided into two groups: the first group of patients without COVID-19 and the second group of patients with COVID-19 who were diagnosed by the attending physician in the inpatient ward. 3 cc of blood samples were taken from each group to determine the total oxidant status (TOS) and TAC. The statistical significance level was set at 0.05.
Results: In comparing OS biomarker factors between healthy and COVID children, this study showed no significant difference in the mean TOS, and TAC between the healthy and diseased groups (P>0.05). There was also no significant difference in mean TOS in different age groups. However, a difference in the mean TAC was observed in groups. In addition, the mean TAC was highest in children under 2 years of age and lowest in the 2-6-year-old group.
Conclusion: The findings of the present study indicate that, in general, the level of OS is not higher in infected patients. This issue is partially compensated by increasing TAC levels, such that the level of OS in patients is not significantly different from that in healthy individuals.
Materials and Methods: In this cross-sectional study, 90 children hospitalized in pediatric wards of Besat Hospital, Hamadan, were included. The patients were divided into two groups: the first group of patients without COVID-19 and the second group of patients with COVID-19 who were diagnosed by the attending physician in the inpatient ward. 3 cc of blood samples were taken from each group to determine the total oxidant status (TOS) and TAC. The statistical significance level was set at 0.05.
Results: In comparing OS biomarker factors between healthy and COVID children, this study showed no significant difference in the mean TOS, and TAC between the healthy and diseased groups (P>0.05). There was also no significant difference in mean TOS in different age groups. However, a difference in the mean TAC was observed in groups. In addition, the mean TAC was highest in children under 2 years of age and lowest in the 2-6-year-old group.
Conclusion: The findings of the present study indicate that, in general, the level of OS is not higher in infected patients. This issue is partially compensated by increasing TAC levels, such that the level of OS in patients is not significantly different from that in healthy individuals.
Type of Study: Research Article |
Subject:
Medicine & Clinical Sciences
Received: 2024/12/25 | Accepted: 2025/04/22 | Published: 2025/08/17
Received: 2024/12/25 | Accepted: 2025/04/22 | Published: 2025/08/17
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