Volume 13, Number 2 (Pajouhan Scientific Journal, Winter 2015)                   psj 2015, 13(2): 1-12 | Back to browse issues page


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Salehzadeh M, Norouzian P, Abbasalipourkabir R. The use of nanoparticles in diagnosis and treatment of breast cancer: A review. psj. 2015; 13 (2) :1-12
URL: http://psj.umsha.ac.ir/article-1-107-en.html

1- Student of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2- Student of Pharmacy, Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- Assistant Professor of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , abbasalipourkabir@yahoo.com
Abstract:   (2275 Views)

Introduction: Nowadays, cancer is one of the most important health concerns in modern societies. The application of nanoparticles has resulted in new possibilities for the diagnosis, tumor imaging and treatment of human cancers.

Methods: Gathering and collecting of data have been done from 56 researches conducted on the structure of types of nanoparticles and their applications in diagnostics, imaging and drug delivery systems for the treatment of cancer.

Results: The inorganic nanoparticles such as quantum dots, which have a central core of magnetic properties, can be used for the detection and imaging of tumors, as well as the organic nanoparticle systems such as liposomes, solid lipid nanoparticles, aptamers, dendrimers and nanobody in different drug-ligands. Aptamers are the oligonucleotids or peptides that bind to the protein or certain targets. Various applications of aptamers include diagnostics, therapeutics, molecular imaging and drug delivery. Moreover, nanobodies are of antibody like molecules which are widely used in the diagnosis and treatment of cancer.

Conclusion: Although there are some challenges and limitations on the use of nanoparticles in medicine, it is hoped that in the near future, nanoparticles create tremendous revolutionary not only in the oncology but also in medicine. The current paper is an overview of the application of organic and inorganic nanoparticles in diagnosis and treatment of the neoplasm.

Full-Text [PDF 936 kb]   (7258 Downloads)    
Type of Study: Review Article | Subject: Basic Sciences
Received: 2014/10/14 | Accepted: 2015/01/30 | Published: 2015/07/16

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