Volume 22, Issue 1 (Pajouhan Scientific Journal, Winter 2024)                   Pajouhan Sci J 2024, 22(1): 22-30 | Back to browse issues page

Research code: 111203-29
Ethics code: IR.GOUMS.REC.1398.308

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Mostaghimi M, Moeini F, Honarvar M R, Sharifi A. Investigation of the Relationship of Autism Spectrum Disorder with Infant Formula Consumption and Employment and Education of the Parents: A Case-Control Study. Pajouhan Sci J 2024; 22 (1) :22-30
URL: http://psj.umsha.ac.ir/article-1-1072-en.html
1- Student Research Committee, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
2- Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran
3- Golestan Research Center of Gastroenterology and Hepatology, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran; and Department of Nutrition and Food Hygiene, Nutrition Health Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , a.sharifi1983@gmail.com
Abstract:   (597 Views)
Background and Objectives: This study explored the association between breastfeeding vs. infant formula and the risk of autism spectrum disorder (ASD), considering parental education and employment as conferring variables.
Materials and Methods: This case-control study was performed on 35 ASD children aged 6-12 years and 70 healthy children matched in terms of age and gender. Age, gender, postnatal nutrition, parental employment, and parental education were recorded with parental cooperation.
Results: There was a statistically significant difference (P=0.005) between the two groups regarding the type of postnatal milk type. Consumption of infant formula alone or combined with breast milk and maternal employment, especially in governmental occupation, were associated with the risk of ASD incidence.
Conclusion: This study provides further evidence of the possible protective effect of exclusive breastfeeding against ASD. In addition, child-mother physical distance due to maternal employment seemed to play a considerable role in the risk of ASD incidence.
Full-Text [PDF 1269 kb]   (119 Downloads)    
Type of Study: Research Article | Subject: Health Sciences
Received: 2023/11/23 | Accepted: 2023/12/3 | Published: 2024/03/19

1. Ghozy S, Tran L, Naveed S, Quynh TTH, Helmy Zayan A, Waqas A, et al. Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian J Psychiatr. 2020;48:101916. [DOI:10.1016/j.ajp.2019.101916] [PMID]
2. Breastfeeding So, Eidelman AI, Schanler RJ, Johnston M, Landers S, Noble L, et al. Breastfeeding and the use of human milk. J Pediatrics. 2012;129(3):e827-e41. [DOI:10.1542/peds.2011-3552] [PMID]
3. WHO. Exclusive breastfeeding for optimal growth, development and health of infants. 2019.
4. Breast milk as the gold standard for protective nutrients. J Pediatr. 2010;156(2 Suppl):S3-7. [DOI:10.1016/j.jpeds.2009.11.021] [PMID]
5. Sayehmiri F, Babaknejad N, Bahrami S, Sayehmiri K, Darabi M, Rezaei-Tavirani M. Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis. Iran J Child Neurol. 2015;9(4):1-9.
6. Bar S, Milanaik R, Adesman A. Long-term neuro-developmental benefits of breastfeeding. Curr Opin Pediatr. 2016;28(4):559-66. [DOI:10.1097/MOP.0000000000000389] [PMID]
7. Manohar H, Pravallika M, Kandasamy P, Chandrasekaran V, Rajkumar RP. Role of Exclusive Breastfeeding in Conferring Protection in Children At-Risk for Autism Spectrum Disorder: Results from a Sibling Case-control Study. J Neurosci Rural Pract. 2018;9(1):132-136. [DOI:10.4103/jnrp.jnrp_331_17] [PMID] []
8. Al-Farsi YM, Al-Sharbati MM, Waly MI, Al-Farsi OA, Al-Shafaee MA, Al-Khaduri MM, et al. Effect of suboptimal breast-feeding on occurrence of autism: A case-control study. J Nutrition. 2012;28(7-8):e27-e32. [DOI:10.1016/j.nut.2012.01.007] [PMID]
9. Schultz ST, Klonoff-Cohen HS, Wingard DL, Akshoomoff NA, Macera CA, Ji M, et al. Breastfeeding, infant formula supplementation, and Autistic Disorder: the results of a parent survey. Int Breastfeed J. 2006;1:16. [DOI:10.1186/1746-4358-1-16] [PMID] []
10. Christensen DL, Maenner MJ, Bilder D, Constantino JN, Daniels J, Durkin MS, et al. Prevalence and characteristics of autism spectrum disorder among children aged 4 years-early autism and developmental disabilities monitoring network, seven sites, United States, 2010, 2012, and 2014. J MMWR Surveillance Summaries. 2019;68(2):1. [DOI:10.15585/mmwr.ss6802a1] [PMID] []
11. Brion MJ, Lawlor DA, Matijasevich A, Horta B, Anselmi L, Araujo CL, et al. What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int J Epidemiol. 2011;40(3):670-80. [DOI:10.1093/ije/dyr020] [PMID] []
12. Moeini F, Mostaghimi M, Honarvar MR, Sharifi A. Comparison of Dietary Intake of Vitamin A in Children with Autism Spectrum Disorders with Healthy Children in Gorgan City in 2021: A Case-control Study. umsha-psj. 2023;21(2):97-103. [DOI:10.61186/psj.21.2.97]
13. Steinman G, Mankuta D. Breastfeeding as a possible deterrent to autism-a clinical perspective. J Medical hypotheses. 2013;81(6):999-1001. [DOI:10.1016/j.mehy.2013.09.013] [PMID]
14. Shamsedine L, Mailhac A, Badaoui A, El Hakim R, Kibbi R, Oueidat H, et al. Breastfeeding association with autism spectrum disorders: A case-control study from Lebanon. Research in Autism Spectrum Disorders. 2020;78:101651. [DOI:10.1016/j.rasd.2020.101651]
15. Westmark CJ. Consumption of breast milk is associated with decreased prevalence of autism in fragile X syndrome. J Nutrients. 2021;13(6):1785. [DOI:10.3390/nu13061785] [PMID] []
16. Belfort MB, Rifas-Shiman SL, Kleinman KP, Guthrie LB, Bellinger DC, Taveras EM, et al. Infant feeding and childhood cognition at ages 3 and 7 years: effects of breastfeeding duration and exclusivity. J JAMA Pediatr. 2013;167(9):836-44. [DOI:10.1001/jamapediatrics.2013.455] [PMID] []
17. Tseng PT, Chen YW, Stubbs B, Carvalho AF, Whiteley P, Tang CH, et al. Maternal breastfeeding and autism spectrum disorder in children: A systematic review and meta-analysis. Nutr Neurosci. 2019;22(5):354-62. [DOI:10.1080/1028415X.2017.1388598] [PMID]
18. Edmunds SR, Kover ST, Stone WL. The relation between parent verbal responsiveness and child communication in young children with or at risk for autism spectrum disorder: A systematic review and meta-analysis. Autism Res. 2019;12(5):715-31. [DOI:10.1002/aur.2100] [PMID] []
19. Perrier C, Corthesy B. Gut permeability and food allergies. Clin Exp Allergy. 2011;41(1):20-8. [DOI:10.1111/j.1365-2222.2010.03639.x] [PMID]
20. Favier CF, Vaughan EE, De Vos WM, Akkermans AD. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol. 2002;68(1):219-26. [DOI:10.1128/AEM.68.1.219-226.2002] [PMID] []
21. Pannaraj PS, Li F, Cerini C, Bender JM, Yang S, Rollie A, et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA pediatrics. 2017;171(7):647-54. [DOI:10.1001/jamapediatrics.2017.0378] [PMID] []
22. Goldsmith F, O'Sullivan A, Smilowitz JT, Freeman SL. Lactation and intestinal microbiota: how early diet shapes the infant gut. J Mammary Gland Biol Neoplasia. 2015;20(3):149-58. [DOI:10.1007/s10911-015-9335-2] [PMID]
23. Hahr JY. Iatrogenic autism. Med Hypotheses. 2013;81(2):251-2. [DOI:10.1016/j.mehy.2013.04.037] [PMID]
24. Lucas RF, Cutler A. Dysregulated Breastfeeding Behaviors in Children Later Diagnosed With Autism. J Perinat Educ. 2015;24(3):171-80. [DOI:10.1891/1058-1243.24.3.171] [PMID] []
25. Guisso DR, Saadeh FS, Saab D, El Deek J, Chamseddine S, El Hassan HA, et al. Association of autism with maternal infections, perinatal and other risk factors: a case-control study. J Autism Dev Disord. 2018;48(6):2010-21. https://doi.org/10.1007/s10803-018-3497-x [DOI:10.1007/s10803-017-3449-x]
26. Brown CM, Austin DW, issues s. Commentary: Fatty acids, breastfeeding and autism spectrum disorder. J E-journal of applied psychology. 2009;5(1):49-52. [DOI:10.7790/ejap.v5i1.158]
27. Brown CM, Austin DW. Autistic disorder and phospholipids: A review. Prostaglandins Leukot Essent Fatty Acids. 2011;84(1-2):25-30. [DOI:10.1016/j.plefa.2010.09.007] [PMID]
28. Austin DW, Busija L, Brown CM. Observable essential fatty acid deficiency markers and autism spectrum disorder. Breastfeed Rev. 2014;22(2):21-6.

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